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Bioorg Med Chem Lett. 2006 Dec 1;16(23):6043-8. Epub 2006 Sep 20.

Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands.

Author information

1
Johnson & Johnson Pharmaceutical Research and Development, L.L.C. 3210 Merryfield Row, San Diego, CA 92121, USA. alee7@prdus.jnj.com <alee7@prdus.jnj.com>

Abstract

A series of 2-arylbenzimidazoles was synthesized and found to bind with high affinity to the human histamine H(4) receptor. Structure-activity relationships were investigated through library preparation and evaluation as well as traditional medicinal chemistry approaches, leading to the discovery of compounds with single-digit nanomolar affinity for the H(4) receptor.

PMID:
16990005
DOI:
10.1016/j.bmcl.2006.08.117
[Indexed for MEDLINE]

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