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Diagn Microbiol Infect Dis. 2007 Mar;57(3):301-7. Epub 2006 Sep 20.

Quantification and identification of polyomavirus DNA in blood and urine of renal transplant recipients.

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  • 1Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.


A cohort of 201 kidney transplant recipients (KTR) including 7 patients with evidence of renal function deterioration (as defined by creatinine levels >20% over baseline values) was analyzed for polyomavirus DNA in blood and urine samples by a new quantitative polymerase chain reaction method. Of 201 patients, 14 (6.9%) were positive for polyomavirus DNA in blood (median level, 500 copies per milliliter of blood) including all 7 patients with renal function deterioration. Polyomavirus DNA detection in blood for diagnosis of renal function deterioration in KTR showed a sensitivity of 100% and a specificity of 96%, whereas positive and negative predictive values were 50% and 100%, respectively. Diagnostic value of decoy cells detection and polyomavirus DNA quantification in urine samples was negligible.

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