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Bioorg Med Chem Lett. 2006 Dec 1;16(23):5982-7. Epub 2006 Sep 20.

Metal complexes with superoxide dismutase-like activity as candidates for anti-prion drug.

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1
Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. t-fukuu@ps.hirokoku-u.ac.jp <t-fukuu@ps.hirokoku-u.ac.jp>

Abstract

Various compounds were evaluated for ability to inhibit the formation of the abnormal protease-resistant form of prion protein (PrP-res) in two cell lines infected with different prion strains. Examination of the structure-activity relationships indicated that compounds with copper-selective chelating ability and whose copper complexes have high SOD-like activity are candidates for anti-prion drug.

PMID:
16987659
DOI:
10.1016/j.bmcl.2006.08.115
[Indexed for MEDLINE]
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