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Cancer Metastasis Rev. 2006 Sep;25(3):323-31.

Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancer.

Author information

1
H. Lee Moffitt Cancer Center, University of South Florida, MRC 2067, 12902 Magnolia Dr, Tampa, FL 33612, USA. kusmars@moffitt.usf.edu

Abstract

It is well established that cancers affect differentiation of dendritic cells and promote systemic expansion of immune suppressive immature myeloid cells. This phenomenon may represent a mechanism of tumor escape from immune attack and could have significant impact on tumor progression. In this review we discuss the role of different tumor-derived factors, which were implicated in abnormal myeloid cell differentiation. The role of reactive oxygen species as well as JAK/STAT signaling in mechanisms of the effects of tumor-derived factors on myeloid cells is also discussed.

PMID:
16983515
PMCID:
PMC1693571
DOI:
10.1007/s10555-006-9002-6
[Indexed for MEDLINE]
Free PMC Article

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