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Nat Rev Genet. 2006 Oct;7(10):781-91.

A tutorial on statistical methods for population association studies.

Author information

1
Department of Epidemiology and Public Health, Imperial College, St Marys Campus, Norfolk Place, London W2 1PG, UK. d.balding@imperial.ac.uk

Abstract

Although genetic association studies have been with us for many years, even for the simplest analyses there is little consensus on the most appropriate statistical procedures. Here I give an overview of statistical approaches to population association studies, including preliminary analyses (Hardy-Weinberg equilibrium testing, inference of phase and missing data, and SNP tagging), and single-SNP and multipoint tests for association. My goal is to outline the key methods with a brief discussion of problems (population structure and multiple testing), avenues for solutions and some ongoing developments.

PMID:
16983374
DOI:
10.1038/nrg1916
[Indexed for MEDLINE]

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