Format

Send to

Choose Destination
Neuron. 2006 Sep 21;51(6):685-90.

Neuronal RNA granules: movers and makers.

Author information

1
Center for Brain Research, Medical University of Vienna, A-1090 Vienna, Austria. michael.kiebler@meduniwien.ac.at

Abstract

RNA localization contributes to cell polarity and synaptic plasticity. Evidence will be discussed that RNA transport and local translation in neurons may be more intimately linked than originally thought. Second, neuronal RNA granules, originally defined as intermediates involved in mRNA transport, are much more diverse in their composition and functions than previously anticipated. We focus on three classes of RNA granules that include transport RNPs, stress granules, and P bodies and discuss their potential functions in RNA localization, microRNA-mediated translational regulation, and mRNA degradation.

PMID:
16982415
DOI:
10.1016/j.neuron.2006.08.021
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center