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J Adolesc Health. 2006 Oct;39(4):607-9. Epub 2006 Jul 10.

Challenges of conducting a placebo-controlled trial for dysmenorrhea in adolescents.

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Department of Obstetrics and Gynecology, Columbia University, New York, New York 10032, USA.


We recruited adolescents to study oral contraceptives versus placebo for dysmenorrhea. We anticipated high discontinuation and concerns about safety, side effects, and sexual behavior. Treatment discontinuation (11%) and loss to follow-up (1%) were lower than expected. The most common reason for nonenrollment was logistical issues (63%). Most participants remained abstinent.

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