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Contraception. 2006 Oct;74(4):328-33. Epub 2006 May 23.

Sublingual versus vaginal misoprostol (400 microg) for cervical priming in first-trimester abortion: a randomized trial.

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  • 1Clínica Mediterrania Médica, Valencia 46017, Castelló, Spain. schja@infomed.sld.cu <schja@infomed.sld.cu>

Abstract

OBJECTIVE:

Our objective was to compare the sublingual administration and the vaginal administration of misoprostol for cervical priming before first-trimester surgical abortion.

DESIGN:

We used an open, multicenter, randomized trial.

LOCATIONS:

We conducted the study in four clinics (in Valencia, Castelló, Murcia and Murcia Capital) in Spain.

PARTICIPANTS:

A total of 1424 healthy pregnant women with amenorrhea of <or=84 days who voluntarily decided to terminate their pregnancy participated in the study.

METHODS:

Women were randomly assigned to receive a single dose of 400 microg of misoprostol either sublingually or vaginally 1-3 h before aspiration.

OUTCOME MEASURES:

The outcome measures assessed were cervical dilation before surgery and surgical time needed for aspiration. The incidence of side effects, such as nausea, vomiting, diarrhea, fever/chills and paresthesia, was evaluated.

RESULTS:

The mean cervical dilation achieved was 6.8+/-0.8 and 6.7+/-0.9 mm for the sublingual and vaginal groups, respectively. The mean surgical time was 7.0+/-2.8 and 7.4+/-2.5 min for the sublingual and vaginal groups, respectively. Nausea, vomiting and diarrhea were more frequent in the sublingual group.

CONCLUSIONS:

Both regimens had equal efficacy; however, the sublingual route caused more side effects.

[PubMed - indexed for MEDLINE]
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