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Acta Cir Bras. 2006 Sep-Oct;21(5):354-6.

Hemorrhoids: an experimental model in monkeys.

Author information

1
Department of Surgery, Federal University of São Paulo (UNIFESP), São Paulo, Brazil. helio@plapler.com.br

Abstract

PURPOSE:

Hemorrhoids are a matter of concern due to a painful outcome. We describe a simple, easy and reliable experimental model to produce hemorrhoids in monkeys.

METHODS:

14 monkeys (Cebus apella) were used. After general anesthesia, hemorrhoids were induced by ligation of the inferior hemorrhoidal vein, which is very alike to humans. The vein was located through a perianal incision, dissected and ligated with a 3-0 vicryl. The skin was sutured with a 4-0 catgut thread. Animals were kept in appropriate cages and evaluated daily.

RESULTS:

Nine days later there were hemorrhoidal piles in the anus in fifty percent (50%) of the animals. Outcome was unremarkable. There was no bleeding and all animals showed no signs of pain or suffering.

CONCLUSION:

This is an affordable and reliable experimental model to induce hemorrhoids for experimental studies.

PMID:
16981041
[Indexed for MEDLINE]
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