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Trends Immunol. 2006 Nov;27(11):493-6. Epub 2006 Sep 18.

Alternative adaptive immunity in invertebrates.

Author information

1
ETH Zürich, Institute for Integrative Biology, Experimental Ecology, ETH-Zentrum, CHN J12.1, CH-8092 Zürich, Switzerland. joachim.kurtz@env.ethz.ch

Abstract

Vertebrate adaptive immunity is characterized by challenge-specific long-term protection. This specific memory is achieved through the vast diversity of somatically rearranged immunological receptors such as antibodies. Whether or not invertebrates are capable of a comparable phenotypic plasticity and memory has long been a matter of debate. A recent study on Anopheles gambiae mosquitoes now establishes Down syndrome cell adhesion molecule (Dscam) as a key immune surveillance factor with characteristics analogous to antibodies.

PMID:
16979938
DOI:
10.1016/j.it.2006.09.001
[Indexed for MEDLINE]

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