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J Neurosurg. 1990 Oct;73(4):623-7.

Whipple's disease presenting with isolated neurological symptoms. Case report.

Author information

1
Department of Neurosurgery, Washington University School of Medicine, St. Louis, Missouri.

Abstract

Whipple's disease is infrequently considered in the differential diagnosis of patients presenting with progressive neurological deterioration. This is in part a result of the relative rarity of this entity and in part due to the more frequent initial presentation of the disease with gastrointestinal, musculoskeletal, or cardiovascular symptoms. A case is described in which the neurological symptoms of progressive dementia and weakness were seen in the relative absence of non-neurological symptomatology. The diagnosis of Whipple's disease was made from a brain biopsy. The neuropathology of Whipple's disease of the central nervous system is described and the importance of considering it as a treatable entity in the differential diagnosis of progressive neurological deterioration, despite the absence of systemic symptomatology, is stressed.

PMID:
1697904
DOI:
10.3171/jns.1990.73.4.0623
[Indexed for MEDLINE]

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