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Curr Opin Biotechnol. 2006 Oct;17(5):548-57. Epub 2006 Sep 15.

Genetic parts to program bacteria.

Author information

1
Biophysics and Chemistry & Chemical Biology, Department of Pharmaceutical Chemistry, University of California San Francisco, QB3 Box 2540, 1700 4th Street, San Francisco, CA 94158, USA. cavoigt@picasso.ucsf.edu

Abstract

Genetic engineering is entering a new era, where microorganisms can be programmed using synthetic constructs of DNA encoding logic and operational commands. A toolbox of modular genetic parts is being developed, comprised of cell-based environmental sensors and genetic circuits. Systems have already been designed to be interconnected with each other and interfaced with the control of cellular processes. Engineering theory will provide a predictive framework to design operational multicomponent systems. On the basis of these developments, increasingly complex cellular machines are being constructed to build specialty chemicals, weave biomaterials, and to deliver therapeutics.

PMID:
16978856
DOI:
10.1016/j.copbio.2006.09.001
[Indexed for MEDLINE]

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