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Fertil Steril. 2006 Nov;86(5):1386-91. Epub 2006 Sep 14.

Early compaction on day 3 may be associated with increased implantation potential.

Author information

1
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

OBJECTIVE:

To determine whether day 3 embryos exhibiting early compaction have an improved implantation potential compared to embryos without compaction.

DESIGN:

A retrospective cohort study.

SETTING:

Hospital-based academic medical center.

PATIENT(S):

Women <38 years of age undergoing IVF cycles between November 2001 and December 2004 having a day 3 transfer of one or two embryos with >8 cells.

INTERVENTION(S):

Standard IVF protocol.

MAIN OUTCOME MEASURE(S):

Compaction grading and implantation rates of 1,047 embryos as related to fragmentation of >or= 8-cell embryos in patients with either 0% or 100% implantation.

RESULT(S):

Compaction grading was strongly associated with implantation potential; however, the direction of this effect depended on the degree of fragmentation. In embryos with <10% fragmentation, implantation rates increased with the degree of compaction (grade 1, 25%; grade 2, 33%; and grade 3, 47%); in embryos with >or=10% fragmentation, the effect was reversed (grade 1, 38%; grade 2, 20%; and grade 3, 9%).

CONCLUSION(S):

Assessing the degree of compaction can be a valuable addition to traditional morphologic assessment in identifying optimal embryos for transfer on day 3.

[Indexed for MEDLINE]

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