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PLoS Comput Biol. 2006 Sep 15;2(9):e122. Epub 2006 Jul 28.

Intricate knots in proteins: Function and evolution.

Author information

1
Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America. virnau@mit.edu

Abstract

Our investigation of knotted structures in the Protein Data Bank reveals the most complicated knot discovered to date. We suggest that the occurrence of this knot in a human ubiquitin hydrolase might be related to the role of the enzyme in protein degradation. While knots are usually preserved among homologues, we also identify an exception in a transcarbamylase. This allows us to exemplify the function of knots in proteins and to suggest how they may have been created.

PMID:
16978047
PMCID:
PMC1570178
DOI:
10.1371/journal.pcbi.0020122
[Indexed for MEDLINE]
Free PMC Article

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