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Science. 2006 Sep 15;313(5793):1591-4.

Vesicle formation at the plasma membrane and trans-Golgi network: the same but different.

Author information

  • 1Department of Biochemistry and Molecular Biology and the Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. mcniven.mark@mayo.edu

Abstract

An elaborate vesicle transport system supports the active exchange of membranes and protein cargo between the plasma membrane and the trans-Golgi network. Many observations suggest that highly conserved mechanisms are used in vesicle formation and scission. Such similarity is found both at the level of the receptor-ligand sequestration process that uses clathrin and associated polymeric and monomeric adaptor proteins, and in the machinery used to deform and vesiculate lipid membranes.

PMID:
16973870
DOI:
10.1126/science.1118133
[PubMed - indexed for MEDLINE]
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