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Antiviral Res. 2007 Feb;73(2):147-50. Epub 2006 Aug 30.

Resistance of herpes simplex virus type 1 to acyclovir: thymidine kinase gene mutagenesis study.

Author information

1
Laboratoire de Virologie Est, Hospices Civils de Lyon, 8 Avenue Rockefeller, 69373 Lyon Cedex 08, France. e.frobert@wanadoo.fr

Abstract

By site-directed mutagenesis, we investigate the role of six mutations of herpes simplex virus type 1 thymidine kinase (TK) gene in the acquisition of resistance to acyclovir (ACV). TK activity was not impaired by substitutions located at codons 17, 161 and 374 and these mutations were thus related to TK gene polymorphism. Mutations His105Pro, Leu364Pro and Asp162Ala lead to the loss of TK activity that could result in ACV-resistance.

PMID:
16970995
DOI:
10.1016/j.antiviral.2006.08.001
[Indexed for MEDLINE]

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