The NeONORM sensitivity parameter

*k*.

**A**. Sign plot and 3D-surface plot for the first order derivative in

*a* of the NeONORM error as a function of the sensitivity parameter

*k* and the normalization factor

*a*. Sign plots are used to illustrate the zero crossings of the function (blue-red and red-blue boundaries). The data represented are a subtraction from two HT29 technical replicates HT29(1) vs. HT29(2).

**B**. As in panel A for a subtraction between the modified, artificial dataset HT29(1)mod

vs. HT29(2). In order to generate the modified dataset, a random chosen quarter of all probe signals of the HT29(1) dataset was individually multiplied with a different random value drawn from a normal distribution with

*μ*=2

^{1.5} and

*σ*=0.1*

*μ*.

**C**. As in panel A, but only a sign plot for the second order derivative in

*a* is shown.

**D**. The NeONORM error function for selected increasing values for

*k* is shown for the HT29(1) vs. HT29(2) (upper) and the HT29(1)mod

vs. HT29(2) datasets. Note that

*k*=0.02 is the flattest curve in both cases.

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