Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Cycle. 2006 Sep;5(17):1946-50. Epub 2006 Sep 1.

The BRCA1 E3 ubiquitin ligase controls centrosome dynamics.

Author information

1
Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. JParvin@rics.bwh.harvard.edu

Abstract

The breast cancer specific tumor suppressor protein 1, BRCA1, mediates functions for all cells to grow. The puzzle of BRCA1 is that its loss is only associated with tumors in breast and ovarian epithelial cells. In this focused review, we highlight the data linking BRCA1 to the centrosome function, and we suggest that the specificity for breast tumors is due to a loss in restraint on centrosome function. Amplification of centrosome numbers secondary to loss of BRCA1 can drive the cell into the aneuploid state, thus, by this perspective loss of BRCA1 is a mutator phenotype.

PMID:
16969086
DOI:
10.4161/cc.5.17.3208
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis
    Loading ...
    Support Center