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Cerebrovasc Dis. 2007;23(1):46-9. Epub 2006 Sep 12.

The alanine/threonine polymorphism of the alpha-1-antichymotrypsin (SERPINA3) gene and ruptured intracranial aneurysms in the Japanese population.

Author information

1
Division of Genetic Diagnosis, Institute of Medical Science, University of Tokyo, Tokyo, Japan. boris@krischek.de

Abstract

BACKGROUND:

Serine protease inhibitor member 3 of clade A (SERPINA3), also known as alpha-1-antichymotrypsin, inhibits the activity of cathepsin G. The release of neutrophil cathepsin G (proteolytic enzyme) can destroy the vascular matrix through degradation, platelet aggregation and coagulation disorders. In a previous report there was evidence that an alanine/threonine polymorphism was associated with the risk factor for aneurysmal subarachnoid hemorrhage (SAH) in a Polish population. We performed this study to determine whether this A15T polymorphism shows the same association in a Japanese population.

METHODS:

A total of 437 patients with an aneurysmal SAH and 405 control cases of Japanese origin were genotyped for the A15T polymorphism and 2 further intronic single nucleotide polymorphisms by using polymerase chain reaction and direct sequencing.

RESULTS:

In the patients with intracranial aneurysms the SERPINA3 A15T allele and genotype distribution did not differ significantly from the controls.

CONCLUSION:

In the Japanese population the A15T polymorphism of the SERPINA3 gene is not associated with aneurysmal SAH.

PMID:
16968986
DOI:
10.1159/000095758
[Indexed for MEDLINE]

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