Format

Send to

Choose Destination
Nature. 1990 Aug 16;346(6285):629-33.

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo.

Author information

1
Institute of Pathology, University Hospital, Zurich, Switzerland.

Abstract

Viruses persist in an immune population, as in the case of influenza, or in an individual, as postulated for human immunodeficiency virus, when they are able to escape existent neutralizing antibody responses by changing their antigens. It is now shown that viruses can in principle escape the immunosurveillance of virus-specific cytotoxic T cells by mutations that alter the relevant T-cell epitope.

PMID:
1696684
DOI:
10.1038/346629a0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center