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Neurology. 2006 Sep 12;67(5):900-1.

A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13.

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1
Center for the Study of Brain Diseases, CHUM Research Center-Notre Dame Hospital, Montreal, Quebec, Canada.

Abstract

The authors investigated genetic factors contributing to restless legs syndrome (RLS) by performing a 10-cM genome-wide scan in a large French-Canadian pedigree. They detected an autosomal-dominant locus mapping to chromosome 20p13, with a maximum multipoint lod score of 3.86 at marker D20S849. This is the third reported autosomal-dominant locus for RLS and the first autosomal-dominant RLS locus in the French-Canadian population.

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