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Neurology. 2006 Sep 12;67(5):875-7.

Late-onset Tay-Sachs disease: adverse effects of medications and implications for treatment.

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  • 1Neuromuscular Division, Department of Neurology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH 44106-5098, USA.


The authors conducted a retrospective and brief prospective study of adverse effects of approximately 350 medications in 44 adults with late-onset Tay-Sachs disease (LOTS). Some medications were relatively safe, whereas others, particularly haloperidol, risperidone, and chlorpromazine, were associated with neurologic worsening.

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