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J Neurovirol. 2006 Aug;12(4):322-7.

Inflammatory response in human tick-borne encephalitis: analysis of postmortem brain tissue.

Author information

1
Institute of Neurology, Medical University of Vienna, Austria.

Abstract

In Central European tick-borne encephalitis (TBE) mechanisms of tissue destruction are poorly understood. To evaluate the contribution of immunological mechanisms to tissue injury, the authors immunohistochemically analyzed paraffin-embedded autoptic brain tissue of 26 human TBE cases. In the parenchymal compartment, there was a predominance of macrophages/microglia and cytotoxic T cells. In addition, it was found that granzyme B-expressing lymphocytes were in close contact with TBE-expressing neurons up-regulating caspase-3. These findings indicate that cellular and humoral pathways of the immune system, especially granzyme B-releasing cytotoxic T cells and macrophages/microglia, mainly contribute to tissue destruction in TBE.

PMID:
16966222
DOI:
10.1080/13550280600848746
[Indexed for MEDLINE]

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