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Eur J Intern Med. 2006 Oct;17(6):430-3.

Extremely elevated C-reactive protein.

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1
Department of General Internal Medicine, University Hospital, Leuven, Herestraat 49, B-3000 Leuven, Belgium.

Abstract

BACKGROUND:

C-reactive protein (CRP) is a widely used inflammatory marker. Yet, the clinical significance and outcome of extremely elevated CRP levels are poorly characterized.

METHODS:

We collected all patients seen at a university hospital in 2004 with at least one CRP level above 500 mg/l and retrospectively analyzed their electronic files, focusing on patient characteristics, clinical diagnosis, microbiology and vital outcome.

RESULTS:

CRP was above 500 mg/l in 130 patients with a median age of 62 years. Patient characteristics, settings, etiologies of inflammation, comorbidities and microbiology varied widely. Infections, mainly bacterial, accounted for 88% of episodes. Outcome was fatal in 36% of all patients and in 61% of patients with active malignancies.

CONCLUSION:

A wide variety of infections, especially bacterial, that are generally readily identified account for the majority of instances of extreme CRP elevation. Mortality is high, certainly in oncological patients.

PMID:
16962952
DOI:
10.1016/j.ejim.2006.02.025
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