Send to

Choose Destination
Clin Exp Rheumatol. 1990 May-Jun;8(3):259-64.

The antiperinuclear factor. I. Clinical and serologic associations.

Author information

Department of Immunology, Brest University Medical School Hospital, France.


The antiperinuclear factor (APF) test raises two main problems: the unpredictability of the cells used as substrate and the difficulty in expressing the results. We propose that 10% of the cells have to be stained by a given serum in order for it to be considered positive. APF were found to be present in 76% of rheumatoid arthritis (RA) patients, 3% of healthy controls and occasionally in disease controls. The production of APF was significantly (p less than 0.01) related to the presence of rheumatoid factor in RA, and IgG antibody was predominant in the APF test.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center