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Clin Microbiol Infect. 2006 Oct;12(10):1030-3.

Treatment of bone and joint infections caused by Gram-negative bacilli with a cefepime-fluoroquinolone combination.

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1
Division of Infectious Diseases, University of Lille, Dron Hospital, Tourcoing, France. laurence.legout@hcuge.ch

Abstract

A 3-year retrospective study evaluated the effectiveness and safety of cefepime plus a fluoroquinolone for treating bone and joint infections caused by Gram-negative bacilli (GNB) in 28 patients. Intra-operative cultures yielded primarily Pseudomonas spp. and Enterobacter cloacae. Full recovery (cure) was observed in 79% of patients. There were no serious adverse effects and no resistant organisms were isolated. The results of the study confirmed the safety and effectiveness of cefepime combined with a fluoroquinolone for the treatment of bone and joint infections caused by Gram-negative bacilli.

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