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Biomacromolecules. 2006 Sep;7(9):2565-74.

Water-soluble poly(ethylenimine)-based nitric oxide donors: preparation, characterization, and potential application in hemodialysis.

Author information

1
Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109-1055, USA.

Abstract

A novel approach to potentially resolve serious thrombosis issues associated with kidney dialysis (hemodialysis) therapies is described. New water-soluble polymeric nitric oxide (NO) donors, based on the diazeniumdiolated branched poly(ethylenimine)s and their derivatives, are prepared and characterized. These macromolecular NO donors (with up to 4.15 micromol/mg of total NO release) are utilized as additives to the dialysate solution of model dialysis filters. The presence of these species can create a localized increase in NO levels at the high surface area dialysis fiber/blood interface within the hemodialyzers. Nitric oxide is a naturally occurring and potent anti-platelet agent and is expected to greatly decrease the risk of thrombosis in the dialysis units.

PMID:
16961319
PMCID:
PMC2532790
DOI:
10.1021/bm060361s
[Indexed for MEDLINE]
Free PMC Article

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