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Effects of mycophenolic acid on high glucose-induced expression of TGF-beta and CTGF in mesangial cells.

Author information

1
Department of Nephrology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China.

Abstract

The effects of mycophenolic acid (MPA) on high glucose-induced expression of transforming growth factor-beta (TGF-beta) and connective tissue growth factor (CTGF) in mesangial cells (MC) were investigated. Rat MC were cultured in the presence of different concentrations of MPA (1.0 and 10.0 micromol/L) or MPA plus high glucose for 72 h. The expression of TGF-beta and CTGF was detected by Western blot. The results showed that high glucose could induce the expression of TGF-beta and CTGF in MC, but MPA could inhibit this effects. MPA did not influence the expression of TGF-beta and CTGF in normal glucose. It was concluded that MPA might prevent the progression of diabetic nephropathy by inhibiting the expression of TGF-beta and CTGF in MC.

PMID:
16961272
DOI:
10.1007/bf02829554
[Indexed for MEDLINE]

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