Format

Send to

Choose Destination
Arch Environ Occup Health. 2005 Jan-Feb;60(1):17-23.

Genetic influences on the retention of inorganic mercury.

Author information

1
Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden.

Abstract

Mercury is eliminated as glutathione (GSH) conjugates. GSH production is mediated by glutamyl-cysteine ligase (GCL), and conjugation by glutathione S-transferases (GST). This study tested if polymorphisms in GCL and GST genes modify mercury retention in humans exposed to elemental mercury vapor. Total mercury concentrations in whole blood, plasma and urine, and genotypes for GCLC, GCLM, GSTA1, GSTM1, GSTP1, and GSTT1 were determined in 309 gold miners, gold buyers and controls. The presence of the GCLM-588T allele was associated with increased blood, plasma and urine mercury levels. These results indicate that genotypes with decreased GSH availability for mercury conjugation affect the metabolism of inorganic mercury.

PMID:
16961004
DOI:
10.3200/AEOH.60.1.17-23
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center