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Mov Disord. 2006 Nov;21(11):1975-7.

Correlation between cardiac 123I-MIBG and odor identification in patients with Parkinson's disease and multiple system atrophy.

Author information

1
Department of Neurology, Ajou University College of Medicine, Suwon, South Korea. phisland@chol.com

Abstract

We investigated an association between olfaction and cardiac (123)I-metaiodobenzylguanidine (MIBG) uptake in patients with Parkinson's disease (PD) and multiple system atrophy (MSA). There was a significant positive correlation between cardiac MIBG uptake and the Cross-Cultural Smell Identification (CCSI) score in patients with PD (r = 0.56; P = 0.003) independent of the disease duration or clinical rating of motor status. However, patients with MSA did not show a significant correlation between cardiac MIBG uptake and the CCSI score. Our findings suggest that the functional losses of the olfactory and cardiac sympathetic systems are closely coupled in PD.

PMID:
16960860
DOI:
10.1002/mds.21083
[Indexed for MEDLINE]

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