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Nature. 1990 Jul 19;346(6281):240-4.

A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif.

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Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.


A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. This gene has been termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-determining gene, TDF.

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