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Child Adolesc Psychiatr Clin N Am. 2006 Oct;15(4):843-68, vii-viii.

Neurobiology of depression in children and adolescents.

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1
Department of Psychiatry, Division of Neuroscience, Columbia University, New York, NY 10032, USA. zalsman@post.tau.ac.il

Abstract

This article reviews classical and updated studies of the neurobiology of depressive disorders in children and adolescents. Most studies of childhood and adolescent depression and suicide have followed up the observations and methods used in studies in adults. These studies include neuroendocrine studies, which particularly look at the hypothalamic-pituitary-adrenal axis, the serotonergic system, peripheral blood and cerebrospinal fluid biologic markers, genetics, gene-environment interactions and sleep studies, and neuroimaging and postmortem studies, although in these areas the number of studies is limited.

PMID:
16952764
DOI:
10.1016/j.chc.2006.05.010
[Indexed for MEDLINE]
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