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J Urol. 2006 Oct;176(4 Pt 1):1372-5.

Combination of oral tramadol, acetaminophen and 1% lidocaine induced periprostatic nerve block for pain control during transrectal ultrasound guided biopsy of the prostate: a prospective, randomized, controlled trial.

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1
Division of Urology, University of Florida, Jacksonville, Florida 32209, USA.

Abstract

PURPOSE:

Prostate biopsy for diagnosing cancer can be painful. Tramadol is a centrally acting analgesic used to treat many pain disorders. We determined whether administering oral tramadol and acetaminophen combined with 1% lidocaine induced periprostatic nerve block would significantly decrease the pain experienced by patients during standard 10-core transrectal ultrasound guided needle biopsy of the prostate.

MATERIALS AND METHODS:

A total of 60 men who presented for diagnostic prostate biopsy were randomized to receive placebo plus periprostatic 1% lidocaine as the control group of 30 or 75 mg tramadol/650 mg acetaminophen orally plus periprostatic 1% lidocaine as the experimental group of 30 before undergoing biopsy. Immediately after biopsy each patient was asked to rate the pain on a linear 10-point scale and a standard 6-point faces pain scale. Complications of pain medication administration in each group were noted and compared.

RESULTS:

Pain medication administration was well tolerated by each study group except for lightheadedness/dizziness and itching in 1 patient each in the experimental group, and lightheadedness/dizziness in 1 patient in the control group. Overall patients in the experimental group reported a mean decrease +/- SD in the pain score of 2.3 +/- 2.4 on the scale of 1 to 10 (p = 0.0008) and 1.11 +/- 1.25 on the scale of 0 to 5 compared with scores in controls (p = 0.0009).

CONCLUSIONS:

Administering 75 mg tramadol/650 mg acetaminophen orally with periprostatic 1% lidocaine before transrectal ultrasound guided prostate biopsy is a safe, easy and effective method of controlling pain during the biopsy procedure.

PMID:
16952635
DOI:
10.1016/j.juro.2006.06.018
[Indexed for MEDLINE]
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