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Biochim Biophys Acta. 2006 Dec;1764(12):1904-13. Epub 2006 Jul 26.

Protein sulfation analysis--A primer.

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Department of Pathology/Enders 1130, Harvard Medical School and Children's Hospital Boston, 320 Longwood Ave, Boston, MA 02115, USA.


The aim of this review is to present an overview of protein sulfation in the context of 'modificomics', i.e. post-translational modification-specific proteome research. In addition to a short introduction to the biology of protein sulfation (part 1), we will provide detailed discussion regarding (i) methods and tools for prediction of protein tyrosine sulfation sites (part 2), (ii) biochemical techniques used for protein sulfation analysis (part 3.1), and (iii) mass spectrometric strategies and methods applied to protein sulfation analysis (part 3.2). We will highlight strengths and limitations of different strategies and approaches (including references), providing a primer for newcomers to protein sulfation analysis.

[Indexed for MEDLINE]

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