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Psychiatry Res. 2006 Oct 30;147(2-3):221-6. Epub 2006 Sep 6.

Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance.

Author information

1
Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy. bertolia@psichiat.uniba.it

Abstract

Earlier studies with functional imaging in schizophrenia have demonstrated dysfunction of the dorsolateral prefrontal cortex during working memory. Controlling for behavioral performance and for catechol-O-methyltransferase (COMT) Val158Met genotype, we here demonstrate in a functional magnetic resonance imaging paradigm that patients recruit greater neuronal resources in prefrontal cortex during working memory, suggesting that this phenotype is a core functional trait of the disease. We also replicated earlier findings that the Val allele of the COMT polymorphism is associated with greater engagement of the prefrontal cortex.

[Indexed for MEDLINE]

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