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Mediators Inflamm. 2006;2006(3):62537.

Suppression of carrageenan- and collagen II-induced inflammation in mice by geranium oil.

Author information

1
Institute of Medical Mycology, Teikyo University, 359 Otsuka, Hachioji, Tokyo 192-0395, Japan.

Abstract

To obtain experimental evidence on the therapeutic efficacy of essential oils in aromatherapy for inflammatory diseases, we examined the effects of geranium oil on carrageenan-induced and collagen II-induced inflammation in mice, to assess acute and chronic anti-inflammatory activities of the oil. Single intraperitoneal injection of 5 mu L of geranium oil clearly suppressed the carrageenan-induced footpaw edema and increase in tissue myeloperoxidase activity, and repeated administration of the oil suppressed collagen-induced arthritis. These results revealed that geranium oil suppressed both acute and chronic inflammatory responses in mice.

PMID:
16951493
PMCID:
PMC1592600
DOI:
10.1155/MI/2006/62537
[Indexed for MEDLINE]
Free PMC Article
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