Format

Send to

Choose Destination
See comment in PubMed Commons below
J Electrocardiol. 2006 Oct;39(4 Suppl):S28-30. Epub 2006 Sep 6.

Noninvasive electrocardiographic imaging of cardiac resynchronization therapy in patients with heart failure.

Author information

1
Cardiac Bioelectricity and Arrhythmia Center, Washington University in St. Louis, St. Louis, MO 63130-4899, USA. rudy@wustl.edu

Abstract

Cardiac resynchronization therapy (CRT) using biventricular (BiV) pacing has been developed to restore synchrony and improve cardiac performance in patients with heart failure. It has been clinically beneficial in 65% to 70% of patients. Being an electrical (pacing) approach, detailed electrical information during CRT is critical in understanding its mechanism and clinical outcome. However, electrical data from patients have been limited because of the requirement for invasive mapping. Electrocardiographic imaging provides the necessary tool to noninvasively obtain this information. We applied electrocardiographic imaging to 8 patients undergoing CRT during their native rhythm and various (single-ventricular and BiV) pacing modes with the following observations: (1) native rhythm activation was heterogeneous with latest activation in lateral left ventricular (LV) base (3 of 6 patients) or in anterolateral, midlateral, or inferior LV; (2) when accompanied by fusion, LV pacing was as effective as BiV; (3) right ventricular pacing was not effective for resynchronization; (4) efficacy of CRT depended strongly on patient-specific electrophysiologic substrate.

[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center