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Cell Metab. 2006 Sep;4(3):179-81.

Is the slippery slope from steatosis to steatohepatitis paved with triglyceride or cholesterol?

Author information

1
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.

Abstract

Accumulation of hepatic lipids has been thought to trigger the inflammation, apoptosis, and fibrosis that characterize progression of hepatic steatosis to steatohepatitis and cirrhosis. In this issue of Cell Metabolism, MarĂ­ et al. (2006) provide evidence for excessive mitochondrial free cholesterol as a cause of the progession of steatosis to more severe liver disease.

PMID:
16950134
DOI:
10.1016/j.cmet.2006.08.010
[Indexed for MEDLINE]
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