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Cell Metab. 2006 Sep;4(3):177-8.

Xenobiotic receptor meets NF-kappaB, a collision in the small bowel.

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1
Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.

Abstract

It has long been appreciated that inflammation and infection reduce drug metabolism and that exposure to drug metabolism-inducing xenobiotics can impair immune function. A new study reveals the mutual repression between the xenobiotic nuclear receptor PXR/SXR and NF-kappaB signaling pathways, providing a molecular mechanism linking xenobiotic metabolism and inflammation (Zhou et al.,).

PMID:
16950133
DOI:
10.1016/j.cmet.2006.08.004
[Indexed for MEDLINE]
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