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Am J Cardiol. 2006 Sep 18;98(6A):14K-20K. Epub 2006 Feb 17.

Pathophysiology of contrast-induced nephropathy.

Author information

1
Southeast Renal Research Institute (SERRI), Charlotte, North Carolina 28028, USA. jtumlin@emory.edu

Abstract

Contrast-induced nephropathy (CIN) is the third leading cause of acute kidney injury in hospitalized patients and is associated with significant patient morbidity. The pathogenesis of CIN is complex and not fully understood, but iodinated contrast agents induce intense and prolonged vasoconstriction at the corticomedullary junction of the kidney. Moreover, high-osmolar dyes directly impair the autoregulatory capacity of the kidney through a loss of nitric oxide production. These effects, coupled with direct tubular toxicity of contrast media, lead to overt acute tubular necrosis and the syndrome of CIN.

PMID:
16949376
DOI:
10.1016/j.amjcard.2006.01.020
[Indexed for MEDLINE]

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