Format

Send to

Choose Destination
See comment in PubMed Commons below
Mol Cell. 2006 Sep 1;23(5):757-64.

Wip1 phosphatase modulates ATM-dependent signaling pathways.

Author information

1
Institute of Molecular and Cell Biology, 61 Bioplis Drive, Proteos, 138673, Singapore.

Abstract

Deletion of Ppm1d, the gene encoding the Wip1 phosphatase, renders cells resistant to transformation and mice resistant to tumor development. Here, we report that deficiency of Wip1 resulted in activation of the ataxia-telangiectasia mutated (ATM) kinase. In turn, overexpression of Wip1 was sufficient to reduce activation of the ATM-dependent signaling cascade after DNA damage. Wip1 dephosphorylated ATM Ser1981, a site critical for ATM monomerization and activation, and was critical for resetting ATM phosphorylation as cells repaired damaged DNA. We propose that the Wip1 phosphatase is an integral component of an ATM-dependent signaling pathway.

PMID:
16949371
DOI:
10.1016/j.molcel.2006.07.010
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center