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Nature. 1975 Sep 18;257(5523):197-203.

Is the evolution of insulin Darwinian or due to selectively neutral mutation?

Abstract

A model for the evolution of insulin mainly in terms of adaptive processes is discussed. The model depends critically on the relationship of sequence changes to the three-dimensional structure and the role of various parts of this structure in the conversion of the proinsulin molecule to the active form, the storage of insulin, its transport to the site of action and its interaction with a receptor.

PMID:
169474
DOI:
10.1038/257197a0
[Indexed for MEDLINE]

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