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J Mammary Gland Biol Neoplasia. 2006 Jan;11(1):27-39.

Inhibitors of insulin-like growth factor signaling: a therapeutic approach for breast cancer.

Author information

1
Department of Medicine and Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware St, SE, Minneapolis, MN 55455, USA. sachd003@umn.edu

Abstract

The peptide growth factors IGF-I and IGF-II not only play a role in the development of the mammary gland but are also implicated in breast cancer. Several reagents disrupting IGF signaling have been developed and clinical trials validating IGF signaling as a target in cancer therapy are underway. This review highlights the approaches to inhibiting IGF signaling in breast cancer.

PMID:
16947084
DOI:
10.1007/s10911-006-9010-8
[Indexed for MEDLINE]

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