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Genome Biol. 2006;7(8):231.

Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi.

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1
Division of Molecular Biology, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, CA 91101, USA.

Abstract

Short hairpin RNAs can provide stable gene silencing via RNA interference. Recent studies have shown toxicity in vivo that appears to be related to saturation of the endogenous microRNA pathway. Will these findings limit the therapeutic use of such hairpins?

PMID:
16942630
PMCID:
PMC1779583
DOI:
10.1186/gb-2006-7-8-231
[Indexed for MEDLINE]
Free PMC Article
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