Format

Send to

Choose Destination
Hum Mutat. 2006 Oct;27(10):1041-6.

Interactive visual analysis of SNP data for rapid autozygosity mapping in consanguineous families.

Author information

1
Leeds Institute for Molecular Medicine, St James's University Hospital, University of Leeds, Leeds, United Kingdom. i.m.carr@leeds.ac.uk

Abstract

Autozygosity mapping of recessive disorders using small numbers of highly inbred families is a powerful tool for disease gene identification. With the advent of cheap rapid methods for whole-genome SNP genotyping, data analysis, rather than laboratory work, has become rate-limiting for this approach. Here, we describe AutoSNPa, a computer program used for handling and visually presenting large amounts of SNP data, in such a way as to facilitate the rapid identification and subsequent scrutiny of autozygous regions.

PMID:
16941472
DOI:
10.1002/humu.20383
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center