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J Infect Dis. 2006 Sep 15;194(6):814-8. Epub 2006 Aug 8.

Staphylococcus aureus nasal carriage is associated with glucocorticoid receptor gene polymorphisms.

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Department of Internal Medicine, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands.


The aim of this study was to determine whether polymorphisms of the glucocorticoid receptor gene, influencing glucocorticoid sensitivity, are associated with persistent nasal carriage of Staphylococcus aureus. Two nasal swab cultures were obtained from each of 2,929 participants. Subjects were classified as persistent carriers (n=563) if both cultures were positive. GG homozygotes of the exon 9beta polymorphism were associated with a 68% reduced risk of persistent S. aureus nasal carriage, whereas carriers of the codon 23 lysine allele displayed an 80% increased risk. Thus, genotype-dependent variation in the sensitivity to glucocorticoids is associated with tolerance toward staphylococcal nasal colonization.

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