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FASEB J. 2006 Sep;20(11):1759-60.

New surprises in genetic coding and how an ingenious experiment was almost scooped, by evolution.

Author information

  • 1Department of Biochemistry and Molecular Pharmacology, Program in Cell Dynamics, University of Massachusetts Medical School, 377 Plantation St., Worcester, MA 01605, USA. thoru.pederson@umassmed.edu

Abstract

In 1962, one of the most creative and cogent experiments on the protein coding problem was published. Now it has been discovered that archaebacteria had been doing a related kind of "experiment" all along. Both involve a trick: changing an amino acid that is already attached to a "correct" transfer RNA.

PMID:
16940146
DOI:
10.1096/fj.06-0902ufm
[PubMed - indexed for MEDLINE]
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