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Ann Allergy Asthma Immunol. 2006 Aug;97(2):164-8.

Penicillin skin testing in pregnant women with a history of penicillin allergy and group B streptococcus colonization.

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1
Department of Allergy, Kaiser Permanente Southern California, San Diego Medical Center, USA.

Abstract

BACKGROUND:

The safety and utility of penicillin skin testing (PST) in pregnant women with a history of penicillin allergy and group B streptococcus (GBS) colonization have not been studied.

OBJECTIVE:

To document the safety and utility of PST in pregnant women with a history of penicillin allergy and GBS colonization.

METHODS:

Pregnant GBS culture-positive women with a history compatible with an IgE-mediated or unknown reaction to a penicillin-class antibiotic were recruited for PST. If PST results were negative, penicillin-class antibiotics were recommended for GBS prophylaxis. Adverse reactions associated with PST or antibiotic use from the time of PST through delivery and 6 months post partum were reported.

RESULTS:

In 56 enrolled patients, there were only 2 mild adverse reactions (4%) associated with PST and 3 positive PST results (5%). Of the 53 PST-negative patients, 47 (89%) received at least 1 course of penicillin. There were 2 delayed-onset rashes associated with the use of intrapartum penicillins and 1 immediate-onset rash with intrapartum vancomycin therapy in a PST-positive woman. There were 7 reactions (6%) associated with 122 antibiotic courses administered.

CONCLUSIONS:

Penicillin skin testing can be performed safelyin pregnant women and, if the results are negative, allows penicillins to be used safely at delivery for GBS prophylaxis.

PMID:
16937745
DOI:
10.1016/S1081-1206(10)60007-5
[Indexed for MEDLINE]

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