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Oncogene. 2006 Aug 28;25(38):5257-62.

Regulation of cellular senescence by Rb2/p130.

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  • 1Heinrich-Pette-Institute for Experimental Virology and Immunology at the University of Hamburg, Martinistr, Hamburg, Germany.

Abstract

Growth regulatory functions of Rb2/p130, which aim at a sustained arrest such as in quiescent or differentiated cells, qualify the protein also to act as a central regulator of growth arrest in cellular senescence. In this respect, Rb2/p130 functions are connected to signaling pathways induced by p53, which is a master regulator in cellular senescence. Here, we summarize the pathways, which specify pRb2/p130 to control this arrest program and distinguish its functions from those of pRb/p105.

PMID:
16936745
DOI:
10.1038/sj.onc.1209613
[PubMed - indexed for MEDLINE]
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