Format

Send to

Choose Destination
Nat Rev Mol Cell Biol. 2006 Aug;7(8):580-8.

Giant proteins that move DNA: bullies of the genomic playground.

Author information

1
Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720-3204, USA.

Abstract

As genetic material DNA is wonderful, but as a macromolecule it is unruly, voluminous and fragile. Without the action of DNA replicases, topoisomerases, helicases, translocases and recombinases, the genome would collapse into a topologically entangled random coil that would be useless to the cell. We discuss the organization, movement and energetics of these proteins that are crucial to the preservation of a molecule that has such beautiful biological but challenging physical properties.

PMID:
16936698
DOI:
10.1038/nrm1982
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center